Multiple sclerosis: major histocompatibility complexity and antigen presentation
نویسندگان
چکیده
منابع مشابه
The major histocompatibility complex and multiple sclerosis: a smoking gun?
There are many theories on the aetiology of multiple sclerosis but most lack much in the way of direct experimental support. Despite overwhelming evidence that the pathogenesis involves an interplay between genetic and environmental effects, progress in identifying the relevant risk factors has been painfully slow and there is practically no understanding about how these might interact and resu...
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OBJECTIVE Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed. METHODS Using a c...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2009
ISSN: 1756-994X
DOI: 10.1186/gm105